Development of a Transdermal Patch of Methadone: in Vitro Evaluation Across Hairless Mouse and Human Cadaver Skin
- 1 January 1996
- journal article
- research article
- Published by Informa UK Limited in Pharmaceutical Development and Technology
- Vol. 1 (3), 285-291
- https://doi.org/10.3109/10837459609022597
Abstract
A 3-day monolithic polyacrylate adhesive dispersion type delivery system containing methadone was fabricated and in vitro permeation through hairless mouse and human cadaver skins was conducted. The effect of skin permeation enhancers was also investigated. Skin permeation rate across human cadaver skin was found to be lower than that of hairless mouse. Skin permeation profiles across both types of skins showed a membrane permeation controlled cumulative amount permeated (Q) versus time (t) relationship. Skin permeation rate was found to be dependent on both adhesive film thickness and loading dose of the drug in the matrix. Effective skin permeation rate across the hairless mouse skin was obtained from a patch with 1.5 mm thickness and 15% w/w loading dose. n-Decylmethyl sulfoxide and Azone were found to produce an effective skin permeation rate of methadone through human cadaver skin at a 5% w/w concentration. These initial studies demonstrated the feasibility of methadone administration through intact skin from a transdermal patch.Keywords
This publication has 9 references indexed in Scilit:
- Transdermal Delivery of Metoprolol II: In-Vitro Skin Permeation and Bioavailability in Hairless RatsJournal of Pharmaceutical Sciences, 1995
- Transdermal Delivery of Buprenorphine through Cadaver SkinJournal of Pharmaceutical Sciences, 1994
- Transdermal delivery of metoprolol I: Comparison between hairless mouse and human cadaver skin and effect of n-decylmethyl sulfoxideInternational Journal of Pharmaceutics, 1992
- In vitro release and permeation of levobunolol from various transdermal formulationsInternational Journal of Pharmaceutics, 1992
- Transdermal-Controlled Administration of OxycodoneJournal of Pharmaceutical Sciences, 1991
- Transdermal Delivery of Narcotic Analgesics: pH, Anatomical, and Subject Influences on Cutaneous Permeability of Fentanyl and SufentanilPharmaceutical Research, 1990
- Transdermal Delivery of Narcotic Analgesics: Comparative Permeabilities of Narcotic Analgesics Through Human Cadaver SkinPharmaceutical Research, 1989
- Comparative in vitro release profiles of marketed nitroglycerin patches by different dissolution methodsJournal of Controlled Release, 1988
- Numerical treatment of laminar flow in helically coiled tubes of square cross section. Part I. Stationary helically coiled tubesAIChE Journal, 1975