The Modeling of the Simultaneous Transport of Solvent and Low-Molecular Compounds in Swelling Polymers

Abstract

Mathematical model has been developed in order to predict the behavior of systems consisting of hydrophylic polymer, water, and low-molecular compound. The model has taken into account the processes of swelling of polymers during water sorption. the existence of embedded form of drug in polymer matrix and some others processes. The dependencies of physico-chemical parameters on concentration of water, drug and on mechanical properties of poiymer were justified by corresponding experimental results. Different ratios of these parameters enable to predict the behavior of matrix systems for controlled release of drugs.