The Presence of icaADBC Is Detrimental to the Colonization of Human Skin by Staphylococcus epidermidis
- 1 October 2008
- journal article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 74 (19), 6155-6157
- https://doi.org/10.1128/aem.01017-08
Abstract
Previous studies have demonstrated that Staphylococcus epidermidis isolates colonizing the skin of healthy humans do not typically encode icaADBC , the genes responsible for the production of polysaccharide intercellular adhesin or biofilms. It was therefore hypothesized that the presence of icaADBC was deleterious to the successful colonization of human skin by S. epidermidis . Using a human skin competition model, it was determined that the strong biofilm-producing S. epidermidis strain 1457 was outcompeted at 1, 3, and 10 days by an isogenic icaADBC mutant (1457 ica :: dhfr ), suggesting a fitness cost for carriage of icaADBC .Keywords
This publication has 14 references indexed in Scilit:
- recA mediated spontaneous deletions of the icaADBC operon of clinical Staphylococcus epidermidis isolates: a new mechanism of phenotypic variationsAntonie van Leeuwenhoek, 2008
- σBand SarA independently regulate polysaccharide intercellular adhesin production inStaphylococcus epidermidisCanadian Journal of Microbiology, 2007
- Clonal Analysis of Staphylococcus epidermidis Isolates Carrying or Lacking Biofilm-Mediating Genes by Multilocus Sequence TypingJournal of Clinical Microbiology, 2005
- A multiplex PCR method for the detection of all five individual genes of ica locus in Staphylococcus epidermidis. A survey on 400 clinical isolates from prosthesis‐associated infectionsJournal of Biomedical Materials Research Part A, 2005
- Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolatesJournal of Medical Microbiology, 2004
- The Bacterial Insertion Sequence Element IS 256 Occurs Preferentially in Nosocomial Staphylococcus epidermidis Isolates: Association with Biofilm Formation and Resistance to AminoglycosidesInfection and Immunity, 2004
- Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteersJournal of Antimicrobial Chemotherapy, 2003
- Screening forStaphylococcus epidermidisMarkers Discriminating between Skin‐Flora Strains and Those Responsible for Infections of Joint ProsthesesThe Journal of Infectious Diseases, 2000
- A novel mechanism of phase variation of virulence in Staphylococcus epidermidis: evidence for control of the polysaccharide intercellular adhesin synthesis by alternating insertion and excision of the insertion sequence element IS256Molecular Microbiology, 1999
- Molecular basis of intercellular adhesion in the biofilm‐forming Staphylococcus epidermidisMolecular Microbiology, 1996