Temporal Trends in Polypharmacy and Hyperpolypharmacy in Older New Zealanders over a 9-Year Period: 2005-2013
- 26 November 2014
- journal article
- Published by S. Karger AG in Gerontology
- Vol. 61 (3), 195-202
- https://doi.org/10.1159/000368191
Abstract
Background: Polypharmacy and hyperpolypharmacy are proxy indicators for inappropriate medicine use. Inappropriate medicine use in older people leads to adverse clinical outcomes. Objective: The objectives of this study were to investigate the prevalence and trends of polypharmacy and hyperpolypharmacy in older people in New Zealand from 2005 to 2013, analyzing the pharmaceutical collections maintained by the Ministry of Health. Methods: A repeated cross-sectional analysis of population-level dispensing data was conducted from January 1, 2005 to December 31, 2013. Polypharmacy and hyperpolypharmacy in individuals were defined as the use of 5-9 medicines and ≥10 medicines, respectively, dispensed concurrently for a period of ≥90 days. Differences in polypharmacy and hyperpolypharmacy between 2005 and 2013 were examined. A multinomial regression model was used to predict sociodemographic characteristics associated with polypharmacy and hyperpolypharmacy. Results: Polypharmacy and hyperpolypharmacy were found to be higher in 2013 compared to 2005 (polypharmacy: 29.5 vs. 23.4%, p < 0.001; hyperpolypharmacy: 2.1 vs. 1.3%, p < 0.001). The risk of polypharmacy and hyperpolypharmacy was higher in females, in those aged 80-84 years, in the Māori population (for polypharmacy) and the Middle Eastern, Latin American, or African population (for hyperpolypharmacy), in people living in the Southern-district health board, and in individuals with increasing deprivation. Conclusion: The population of New Zealand is aging and the number of older people with multiple chronic conditions is increasing. The proportion of older people exposed to polypharmacy and hyperpolypharmacy has increased in 2013 compared to 2005. Our study provides important information to alert health policy makers, researchers, and clinicians about the dire need to reduce the medication burden in older New Zealanders.Keywords
This publication has 25 references indexed in Scilit:
- High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population levelBMC Public Health, 2013
- Association of polypharmacy with nutritional status, functional ability and cognitive capacity over a three‐year period in an elderly populationPharmacoepidemiology and Drug Safety, 2011
- Increasing polypharmacy - an individual-based study of the Swedish population 2005-2008BMC Clinical Pharmacology, 2010
- Patterns of Drug Use and Factors Associated with Polypharmacy and Excessive Polypharmacy in Elderly PersonsDrugs & Aging, 2009
- Utilization of evidence-based therapy for the secondary prevention of acute coronary syndromes in Australian practiceJournal of Clinical Pharmacy & Therapeutics, 2008
- Clinical pharmacology in the geriatric patientFundamental & Clinical Pharmacology, 2007
- Polypharmacy in elderly patients at discharge from the acute care hospitalTherapeutics and Clinical Risk Management, 2007
- JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practiceHeart, 2005
- Polypharmacy in the elderly: A literature reviewJournal of the American Academy of Nurse Practitioners, 2005
- Heart failure: Evaluation and care of patients with left ventricular systolic dysfunctionJournal of Cardiac Failure, 1995