Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
- 27 April 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 40 (6), 713-715
- https://doi.org/10.1038/ng.148
Abstract
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.Keywords
This publication has 10 references indexed in Scilit:
- Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease lociProceedings of the National Academy of Sciences, 2007
- Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease GenePLOS ONE, 2007
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature, 2007
- Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetesNature Genetics, 2007
- Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityNature Genetics, 2007
- Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4PLoS Genetics, 2007
- Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesisNature Genetics, 2007
- A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1Nature Genetics, 2006
- A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease GeneScience, 2006
- Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's diseaseHuman Molecular Genetics, 2005