Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins
Open Access
- 22 December 2003
- journal article
- review article
- Published by Wiley in International Journal of Cancer
- Vol. 109 (2), 157-162
- https://doi.org/10.1002/ijc.11691
Abstract
Genomic instability is a hallmark of most human cancers including high‐risk human papillomavirus (HPV)‐associated anogenital neoplasia. The two HPV‐encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV‐induced genomic instability and discuss its significance in the context of human carcinogenesis.Keywords
Funding Information
- National Cancer Institute (CA66980)
- Deutsche Forschungsgemeinschaft
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