Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics
- 8 October 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Annals of Biomedical Engineering
- Vol. 47 (1), 39-59
- https://doi.org/10.1007/s10439-018-02145-5
Abstract
Pentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent, anti-diabetic agent, enzymatic resistant properties, etc. This review article focuses on the important benefits of PGG on vascular health, including its role in tissue mechanics, the different modes of pharmacological administration (e.g., oral, intravenous and endovascular route, intraperitoneal route, subcutaneous route, and nanoparticle based delivery and microbubble-based delivery), and its potential therapeutic role in vascular diseases such as abdominal aortic aneurysms (AAA). In particular, the use of PGG for AAA suppression and prevention has been demonstrated to be effective only in the calcium chloride rat AAA model. Therefore, in this critical review we address the challenges that lie ahead for the clinical translation of PGG as an AAA growth suppressor.Keywords
Funding Information
- American Heart Association (16CSA28480006)
This publication has 158 references indexed in Scilit:
- Lung Surfactant Microbubbles Increase Lipophilic Drug Payload for Ultrasound-Targeted DeliveryTheranostics, 2013
- Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen‐specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activationFEBS Open Bio, 2013
- Molecular Imaging of Experimental Abdominal Aortic AneurysmsThe Scientific World Journal, 2013
- Preparation of penta-O-galloyl-β-d-glucose from tannic acid and plasma pharmacokinetic analyses by liquid–liquid extraction and reverse-phase HPLCJournal of Pharmaceutical and Biomedical Analysis, 2011
- Quantitative Assessment of Abdominal Aortic Aneurysm GeometryAnnals of Biomedical Engineering, 2010
- Design and Testing of a Pulsatile Conditioning System for Dynamic Endothelialization of Polyphenol-Stabilized Tissue Engineered Heart ValvesCardiovascular Engineering and Technology, 2010
- Drug Delivery Systems for Intraperitoneal TherapyPharmaceutical Research, 2010
- Association of statin prescription with small abdominal aortic aneurysm progressionAmerican Heart Journal, 2010
- Anti-Cancer, Anti-Diabetic and Other Pharmacologic and Biological Activities of Penta-Galloyl-GlucosePharmaceutical Research, 2009
- Protein Binding and Astringent Taste of a Polymeric Procyanidin, 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose, Castalagin, and GrandininJournal of Agricultural and Food Chemistry, 2006