Adverse Effects of Monosodium Glutamate on Liver and Kidney Functions in Adult Rats and Potential Protective Effect of Vitamins C and E
Open Access
- 1 January 2012
- journal article
- Published by Scientific Research Publishing, Inc. in Food and Nutrition Sciences
- Vol. 03 (05), 651-659
- https://doi.org/10.4236/fns.2012.35089
Abstract
Monosodium glutamate (MSG) was administrated to rats at doses of 0.6 and 1.6 mg/g body weight for 14 days. Body weight and relative liver and kidney weight of rats were significantly increased. On regard to liver functions, the activities of alanine aminotransferase (ALT) and γ glutamyle transferase (GGT) significantly increased in the serum, on MSG administration, meanwhile, serum total protein, albumin and serum total bilirubin significantly decreased. MSG had adverse effects on kidney functions as serum urea and serum creatinine were significantly increased. Vitamin C (0.3 mg/g body weight) and vitamin E (0.2 mg/g body weight) co-adminstrated with MSG, significantly restored the body weight and relative liver and kidney weights to control levels. In the presence of vitamin C and vitamin E the activities of ALT and GGT in the serum were also significantly reduced to become comparable with control trail. Consequently, serum total protein, albumin and serum total bilirubin were significantly increased in the serum, while serum urea and serum creatinine were significantly decreased after administration of each vitamin. The results showed that MSG at doses of 0.6 and 1.6 mg/g of body weight may cause an adverse effect on the hepatic and renal functions which might be due to oxidative stress induced by MSG on the liver and renal tissue. Supplementation of vitamin C and vitamin E was capable of ameliorating MSG-induced oxidative stress on hepatic and renal functions.Keywords
This publication has 22 references indexed in Scilit:
- Vitamin E Protects Against Oxidative Damage Caused by Formaldehyde in the Liver and Plasma of RatsMolecular and Cellular Biochemistry, 2006
- Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: Biochemical and histological studiesJournal of Chemical Neuroanatomy, 2005
- Fighting the stranger—antioxidant protection against endotoxin toxicityToxicology, 2002
- α-Tocopherol modulates liver toxicity of the pyrethroid cypermethrinToxicology Letters, 2001
- Effect of vitamin E and selenium on resistance to oxidative stress in chicken superficial pectoralis muscleComparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2001
- Protective effect of vitamin E, β-carotene and N-acetylcysteine from the brain oxidative stress induced in rats by lipopolysaccharideThe International Journal of Biochemistry & Cell Biology, 2001
- The toxicity/safety of processed free glutamic acid (MSG): A study in suppression of informationAccountability in Research, 1999
- Hyperphagia and Weight Gain after Gold-Thioglucose: Relation to Hypothalamic Neuropeptide Y and ProopiomelanocortinEndocrinology, 1998
- Interaction of vitamin C and vitamin E during free radical stress in plasma: An ESR studyFree Radical Biology & Medicine, 1993
- Umami and appetite: Effects of monosodium glutamate on hunger and food intake in human subjectsPhysiology & Behavior, 1990