Genetic Aspects of Unconventional Virus Infections: The Basis of the Virino Hypothesis
- 28 September 2007
- book chapter
- review article
- Published by Wiley in Ciba Foundation symposium
- Vol. 135, 63-83
- https://doi.org/10.1002/9780470513613.ch5
Abstract
The properties of genes involved directly or indirectly in the pathogenesis of scrapie and other unconventional (UCV) virus infections are reviewed. Reasons are presented for assigning paramount importance to the Sinc gene in mice and the Sip gene in sheep (the likely homologue of Sinc). The rationale is given for concluding that the agents of UCV infections have their own genomic molecules coding for strain differences. The virino hypothesis, which proposes that the infective form of the agent is an informational hybrid between the agent's genome and protective host proteins, is presented in detail, with an explanation of the postulated role of Sinc.This publication has 27 references indexed in Scilit:
- Linkage of the Scrapie-associated Fibril Protein (PrP) Gene and Sinc Using Congenic Mice and Restriction Fragment Length Polymorphism AnalysisJournal of General Virology, 1987
- Temporary and Permanent Modifications to a Single Strain of Mouse Scrapie on Transmission to Rats and HamstersJournal of General Virology, 1987
- Genetic Control of Scrapie: Incubation Period and Plaque Formation in I MiceJournal of General Virology, 1987
- Biological Evidence that Scrapie Agent Has an Independent GenomeJournal of General Virology, 1987
- Biochemical Differences among Scrapie-associated Fibrils Support the Biological Diversity of Scrapie AgentsJournal of General Virology, 1985
- Selection of Swaledale sheep of reduced susceptibility to experimental scrapieVeterinary Record, 1985
- Scrapie agent: prions or virinos?Nature, 1982
- Extraneural competition between different scrapie agents leading to loss of infectivityNature, 1975
- An analysis of natural scrapie in suffolk sheepHeredity, 1965