Increase in kinins on post-exercise hypotension in normotensive and hypertensive volunteers
- 1 May 2007
- journal article
- clinical trial
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 388 (5), 533-540
- https://doi.org/10.1515/bc.2007.055
Abstract
Post-exercise hypotension is an important event for blood pressure regulation, especially in hypertensive individuals. Although post-exercise hypotension is a well-known phenomenon, the mechanism responsible is still unclear. The kallikrein-kinin system is involved in blood pressure control, but its role in post-exercise hypotension has not yet been investigated. Thus, the purpose of this study was to investigate the involvement of the vasodilators bradykinin and des-Arg9-BK and kallikrein activity in post-exercise hypotension promoted by 35 min of cycle ergometer (CE) or circuit weight-training (CWT) bouts in normotensive and hypertensive individuals. A significant decrease in mean arterial pressure at 45 and 60 min after CE and 45 min after CWT was observed in normotensive individuals. Hypertensive values of mean arterial pressure were significantly reduced at 45 and 60 min after CE and at 60 min after CWT. Before exercise, plasma bradykinin concentrations and kallikrein activity were higher in hypertensive compared to normotensive volunteers. Kinin levels increased in the groups evaluated at the end of the training period and 60 min post-exercise. These data suggest that the kallikrein-kinin system may be involved in post-exercise hypotension in normotensive and hypertensive individuals subjected to CE and CWT bouts.Keywords
This publication has 41 references indexed in Scilit:
- The Anti-Hypertensive Effects of ExerciseSports Medicine, 2006
- Recommendations for Blood Pressure Measurement in Humans and Experimental AnimalsHypertension, 2005
- Hormonal Responses and Adaptations to Resistance Exercise and TrainingSports Medicine, 2005
- Contraction‐related factors affect the concentration of a kallidin‐like peptide in rat muscle tissueThe Journal of Physiology, 2002
- Exercise‐induced increase in interstitial bradykinin and adenosine concentrations in skeletal muscle and peritendinous tissue in humansThe Journal of Physiology, 2002
- Potential causes, mechanisms, and implications of post exercise hypotensionJournal of Human Hypertension, 2002
- Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein geneThe FASEB Journal, 2000
- Involvement of bradykinin in acute exercise-induced increase of glucose uptake and GLUT-4 translocation in skeletal muscle: Studies in normal and diabetic humans and ratsMetabolism, 2000
- Bradykinin B 2 Receptor Antagonism Attenuates Blood Pressure Response to Acute Angiotensin-Converting Enzyme Inhibition in Normal MenHypertension, 2000
- Blood pressure regulation by the kallikrein-kinin systemGeneral Pharmacology: The Vascular System, 1996