Differences in the Compressive Stress-Strain Response of Infiltrating Ductal Carcinomas with and without Lobular Features ? Implications for Mammography and Elastography
- 1 July 2003
- journal article
- Published by SAGE Publications in Ultrasonic Imaging
- Vol. 25 (3), 162-170
- https://doi.org/10.1177/016173460302500304
Abstract
In a previous study, it was noted that in some cases when compressive strains greater than about 5% were applied to tumors removed from the breast, there was an abrupt and irreversible change in the tissue stiffness. The data from that study were further analyzed and infiltrating ductal carcinomas with and without lobular features were selected for additional testing to explore their behavior under compressive strains from 0–10%. Fresh tumor samples were tested using a servo-hydraulic Instron testing machine to apply ramp type displacement loads to the samples. The results show that when strains greater than 5% are applied to the tumor tissue without lobular features, there is an irreversible decrease in the stiffness of the tissue while no such change is noted in the other tumor tissue. The implications for this behavior in making mammographic and elastographic images of the breast were then explored using finite element simulations to determine under what compression conditions could the critical strain threshold be reached in the tumor tissue.Keywords
This publication has 7 references indexed in Scilit:
- Elastic Moduli of Breast and Prostate Tissues under CompressionUltrasonic Imaging, 1998
- Elastostatics of a spherical inclusion in homogeneous biological mediaPhysics in Medicine & Biology, 1998
- Fundamental limitations on the contrast-transfer efficiency in elastography: An analytic studyJapanese Journal of Clinical Oncology, 1996
- Breast compression: a preliminary studyJournal of Biomedical Engineering, 1993
- Axial stress distributions between coaxial compressors in elastography: An analytical modelJapanese Journal of Clinical Oncology, 1992
- X-ray mammography and breast compressionThe Lancet, 1992
- Breast compression to increase the sensitivity of lightscanning for the detection of carcinoma: potential hazard?Journal of Biomedical Engineering, 1992