Prevalence and associations of hepatitis C viremia in hemodialysis patients at a tertiary care hospital
Open Access
- 1 January 2009
- journal article
- research article
- Published by Medknow in Indian Journal of Nephrology
- Vol. 19 (2), 62-67
- https://doi.org/10.4103/0971-4065.53324
Abstract
Hepatitis C virus (HCV) infection in hemodialysis (HD) is a significant problem. We evaluated the prevalence and associations of HCV viremia in our HD patients. All patients undergoing maintenance HD at our center were tested for HCV RNA by PCR after written informed consent. Detailed history regarding age, sex, and duration of dialysis, frequency of dialysis, blood transfusions in one year, number of dialysis centers, dialyzer reuse/fresh use, and recent laboratory data was recorded. A total of 119 patients (77 males and 42 females) were tested for HCV RNA. Thirty three (27.7%) tested positive. Duration of dialysis was significantly longer in HCV RNA positive group ( P = 0.001). 45.2% of patients with duration of dialysis more than 16 months were HCV RNA positive while only 7.4% of patients with dialysis duration ≤16 months were HCV RNA positive ( P P = 0.024). Binary logistic regression analysis showed albumin, duration of dialysis, and serum ALT to be significant variables. Sensitivity and specificity of anti-HCV ELISA was 72.7 and 97.7%, respectively. Prevalence of HCV RNA in the HD population is 27.7%. Duration of dialysis, getting dialysis at more than one center, elevated transaminase levels, and low serum albumin are important associations for HCV RNA positivity.Keywords
This publication has 24 references indexed in Scilit:
- Patterns of hepatitis C prevalence and seroconversion in hemodialysis units from three continents: The DOPPSKidney International, 2004
- Diagnostic Workup of Hepatitis C and the Patient on Maintenance DialysisThe International Journal of Artificial Organs, 2001
- Recommendations for preventing transmission of infections among chronic hemodialysis patients.2001
- Serum Alanine Aminotransferase in Hepatitis C Screening of Patients on HemodialysisAmerican Journal of Kidney Diseases, 2001
- National Surveillance of Dialysis‐Associated Diseases in the United States, 1997Seminars in Dialysis, 2000
- Anti-HCV seropositivity among haemodialysis patients of Iranian originNephrology Dialysis Transplantation, 1999
- Serologic survey for control of hepatitis C in haemodialysis patients: third-generation assays and analysis of costsNephrology Dialysis Transplantation, 1997
- Declining value of alanine aminotransferase in screening of blood donors to prevent posttransfusion hepatitis B and C virus infection. The Retrovirus Epidemiology Donor StudyTransfusion, 1995
- Incidence of and risk factors for hepatitis B virus and hepatitis C virus infection among haemodialysis and CAPD patients: evidence for environmental transmissionNephrology Dialysis Transplantation, 1995
- The Declining Risk of Post-Transfusion Hepatitis C Virus InfectionThe New England Journal of Medicine, 1992