Paget'S disease of the skin. A unifying concept of histogenesis
- 14 November 1982
- Vol. 50 (10), 2203-2206
- https://doi.org/10.1002/1097-0142(19821115)50:10<2203::aid-cncr2820501037>3.0.co;2-3
Abstract
Utilizing the peroxidase antiperoxidase technique we explored the presence and the distribution of carcinoembryonic antigen (CEA) in seven cases of mammary and sixteen of extramammary Paget'S disease of skin. In every case positive immunostaining was observed in all the Paget'S cells and the underlying tumor (where one was present), whereas intervening keratinocytes and melanocytes did not stain. CEA was also present in the cells and secretions of normal eccrine and apocrine glands. Our observations confirm that Paget'S cells are of glandular origin.This publication has 9 references indexed in Scilit:
- Carcinoembryonic antigen present in human eccrine sweatJournal of the American Academy of Dermatology, 1981
- Pagetʼs disease of the vulva A histogenetic study of five cases including ultrastructural observations and review of the literatureThe American Journal of Surgical Pathology, 1977
- Extramammary pacet's disease of the vulva:A clinicopathologic study of 13 casesCancer, 1977
- Electron microscopy in in situ and invasive vulvar Paget's diseaseAmerican Journal of Obstetrics and Gynecology, 1972
- Ultrastructure of perianal Paget's diseaseCancer, 1972
- Ultrastructural Study of a Case of Extramammary Paget's Disease of the VulvaArchives of Dermatology, 1972
- Fine structure of the extramammary Paget's cellCancer, 1971
- The nature of the nipple changes in Paget's diseaseThe Journal of Pathology and Bacteriology, 1962