In vivo detection of brain glycine with echo‐time‐averaged 1H magnetic resonance spectroscopy at 4.0 T
Open Access
- 1 February 2006
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 55 (3), 681-686
- https://doi.org/10.1002/mrm.20807
Abstract
A single‐voxel proton magnetic resonance spectroscopy (1H‐MRS) method is described that enables the in vivo measurement of endogenous brain glycine (Gly) levels in human subjects. At 4.0 T, TE‐averaging 1H‐MRS dramatically attenuates the overlapping myo‐inositol (mI) resonances at 3.52 ppm, permitting a more reliable measure of the Gly singlet peak. This methodology initially is described and tested in phantoms. The phantom data infers that the 3.55‐ppm peak predominantly is Gly with a smaller contribution from mI. The composite resonance thus is differentiated from pure Gly and mI and is labeled Gly*. The mI contribution was calculated as 1H‐MRS data from the occipital cortex of healthy control subjects. The resultant spectra closely resembled experimental phantom data. LC‐model analysis provided a means for quantifying TE‐averaged 1H‐MRS spectra and a mean test–retest variability measure of 15% was established for brain Gly* levels in studies of six healthy subjects. Magn Reson Med, 2006.Keywords
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