Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks

Abstract

Quiz Ref ID Hereditary angioedema with C1 inhibitor deficiency is a rare autosomal dominant disorder due to C1 inhibitor deficiency (type I) or dysfunction (type II) that leads to dysregulated plasma kallikrein activity, excess bradykinin production, and unpredictable potentially life-threatening recurrent angioedema attacks.^1,2 Patients with hereditary angioedema are often limited in their ability to perform daily activities at work, school, or home; experience symptoms of anxiety and depression; face a risk of asphyxiation due to laryngeal attacks; and report poor health-related quality of life.^3-5