Associations of diabetes mellitus with site-specific cancer mortality in the Asia-Pacific region
- 12 August 2010
- journal article
- research article
- Published by Elsevier BV in Annals of Oncology
- Vol. 22 (3), 730-738
- https://doi.org/10.1093/annonc/mdq405
Abstract
Background: Owing to the increasing prevalence of obesity and diabetes in Asia, and the paucity of studies, we examined the influence of raised blood glucose and diabetes on cancer mortality risk. Materials and methods: Thirty-six cohort Asian and Australasian studies provided 367 361 participants (74% from Asia); 6% had diabetes at baseline. Associations between diabetes and site-specific cancer mortality were estimated using time-dependent Cox models, stratified by study and sex, and adjusted for age. Results: During a median follow-up of 4.0 years, there were 5992 deaths due to cancer (74% Asian; 41% female). Participants with diabetes had 23% greater risk of mortality from all-cause cancer compared with those without: hazard ratio (HR) 1.23 [95% confidence interval (CI) 1.12, 1.35]. Diabetes was associated with mortality due to cancer of the liver (HR 1.51; 95% CI 1.19, 1.91), pancreas (HR 1.78; 95% CI 1.20, 2.65), and, less strongly, colorectum (HR 1.32; 95% CI 0.98, 1.78). There was no evidence of sex- or region-specific differences in these associations. The population attributable fractions for cancer mortality due to diabetes were generally higher for Asia compared with non-Asian populations. Conclusion: Diabetes is associated with increased mortality from selected cancers in Asian and non-Asian populations.Keywords
This publication has 51 references indexed in Scilit:
- Epidemiological aspects of neoplasms in diabetesActa Diabetologica, 2010
- Adult height and cancer mortality in Asia: the Asia Pacific Cohort Studies CollaborationAnnals of Oncology, 2009
- Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes MellitusGastroenterology, 2008
- Tobacco smoking and cancer: A meta‐analysisInternational Journal of Cancer, 2007
- The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwideJournal of Hepatology, 2006
- Cohort profile: the Asia Pacific Cohort Studies CollaborationInternational Journal of Epidemiology, 2006
- The burden of cancer attributable to alcohol drinkingInternational Journal of Cancer, 2006
- Diabetes, insulin and risk of cancerMethods and Findings in Experimental and Clinical Pharmacology, 2006
- Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall studyCancer Causes & Control, 2004
- Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. AdultsNew England Journal of Medicine, 2003