Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
Open Access
- 19 January 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 13 (4), 752-755
- https://doi.org/10.1021/ol102991d
Abstract
A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam’s structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM).Keywords
Funding Information
- National Institutes of Health
- National Science Foundation
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