Migraine changes the brain
- 1 June 2012
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Neurology
- Vol. 25 (3), 252-262
- https://doi.org/10.1097/wco.0b013e3283532ca3
Abstract
Purpose of review This review summarizes key findings of the current literature on functional neuroimaging in migraine and describes how these studies have changed our view of the disorder. Recent findings Recent studies have started not only to investigate the global cerebral activation pattern during migraine attacks, but to address specific aspects of migraine attacks such as photophobia, osmophobia as well as pain perception with the aim of disentangling the underlying mechanisms. There is also more and more evidence that the migraine brain is abnormal even outside of attacks and that repeated attacks are leading to functional and structural alterations in the brain, which may in turn drive the transformation of migraine to its chronic form. Some new results are pinpointing toward a potential role of interesting new brain areas in migraine pathophysiology such as the temporal cortex or the basal ganglia. Summary Neuroimaging studies are beginning to shed light on the mechanisms underlying the development and evolution of migraine and its specific symptoms. Future studies have the potential to also improve our understanding of established and upcoming treatment approaches and to monitor treatment effects in an objective and noninvasive way.Keywords
This publication has 85 references indexed in Scilit:
- CNS animal fMRI in pain and analgesiaNeuroscience & Biobehavioral Reviews, 2011
- Activation of central trigeminovascular neurons by cortical spreading depressionAnnals of Neurology, 2010
- Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1Nature Genetics, 2010
- Alterations in brain structure and functional connectivity in prescription opioid-dependent patientsBrain, 2010
- Global and local fMRI signals driven by neurons defined optogenetically by type and wiringNature, 2010
- Thalamic sensitization transforms localized pain into widespread allodyniaAnnals of Neurology, 2010
- A neural mechanism for exacerbation of headache by lightNature Neuroscience, 2010
- Coding of pleasant touch by unmyelinated afferents in humansNature Neuroscience, 2009
- Coordinate‐based activation likelihood estimation meta‐analysis of neuroimaging data: A random‐effects approach based on empirical estimates of spatial uncertaintyHuman Brain Mapping, 2009
- A Positron Emission Tomographic Study in Spontaneous MigraineArchives of Neurology, 2005