Seborrheic Keratosis: An Acantholytic Variant

Abstract

Seborrheic keratoses on the abdomen reported in 2 elderly women show peculiar histologic appearance characterized by prominent acantholysis. The basic histologic architecture was a papillomatous acanthoma corresponding to that of seborrheic keratosis, but the upper portion of the lesions showed extensive acantholytic changes and dyskeratotic cells. Differentiation from seborrheic keratosis with focal acantholytic dyskeratosis, warty dyskeratoma, keratosis senilis and acantholytic squamous cell carcinoma was made based on clinical and histological features. This may be a rare variant of irritated seborrheic keratosis.