Early thalamic lesions in patients with sleep-potentiated epileptiform activity
- 29 May 2012
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 78 (22), 1721-1727
- https://doi.org/10.1212/wnl.0b013e3182582ff8
Abstract
Objective: To compare the prevalence and type of early developmental lesions in patients with a clinical presentation consistent with electrical status epilepticus in sleep either with or without prominent sleep-potentiated epileptiform activity (PSPEA). Methods: We performed a case-control study and enrolled patients with 1) clinical features consistent with electrical status epilepticus in sleep, 2) ≥1 brain MRI scan, and 3) ≥1 overnight EEG recording. We quantified epileptiform activity using spike percentage, the percentage of 1-second bins in the EEG tracing containing at least 1 spike. PSPEA was present when spike percentage during non-REM sleep was ≥50% than spike percentage during wakefulness. Results: One hundred patients with PSPEA (cases) and 47 patients without PSPEA (controls) met the inclusion criteria during a 14-year period. Both groups were comparable in terms of clinical and epidemiologic features. Early developmental lesions were more frequent in cases (48% vs 19.2%, p = 0.002). Thalamic lesions were more frequent in cases (14% vs 2.1%, p = 0.037). The main types of early developmental lesions found in cases were vascular lesions (14%), periventricular leukomalacia (9%), and malformation of cortical development (5%). Vascular lesions were the only type of early developmental lesions that were more frequent in cases (14% vs 0%, p = 0.005). Conclusions: Patients with PSPEA have a higher frequency of early developmental lesions and thalamic lesions than a comparable population of patients without PSPEA. Vascular lesions were the type of early developmental lesions most related to PSPEA.This publication has 25 references indexed in Scilit:
- Continuous Spike and Waves During Sleep and Electrical Status Epilepticus in SleepJournal of Clinical Neurophysiology, 2011
- A Clinical and EEG Study on Idiopathic Partial Epilepsies with Evolution into ESES Spectrum DisordersEpilepsia, 2005
- Primary neonatal thalamic haemorrhage and epilepsy with continuous spike-wave during sleep: a longitudinal follow-up of a possible significant relationEuropean Journal of Paediatric Neurology, 2001
- Circadian rhythms: interactions with seizures and epilepsyEpilepsy Research, 2000
- Encephalopathy with electrical status epilepticus during slow sleep or ESES syndrome including the acquired aphasiaClinical Neurophysiology, 2000
- Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical NetworksJournal of Neuroscience, 2000
- Continuous Spike‐and‐Wave Activity During Slow‐Wave Sleep: Syndrome or EEG Pattern?Epilepsia, 1999
- Late Primary Unilateral Thalamic Hemorrhage in Infancy: Report of Two CasesNeuropediatrics, 1999
- Proposal for Revised Classification of Epilepsies and Epileptic SyndromesEpilepsia, 1989
- Subclinical "Electrical Status Epilepticus" Induced by Sleep in ChildrenArchives of Neurology, 1971