Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study)
Open Access
- 18 May 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Musculoskeletal Disorders
- Vol. 18 (1), 201
- https://doi.org/10.1186/s12891-017-1565-6
Abstract
To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. In a prospective cohort study, data from the second and third survey of the Nord-Trøndelag Health Study were linked to the Norwegian Arthroplasty Register in order to identify total hip or knee replacement as a result of primary osteoarthritis. Among 37 891 participants without previously known thyroid disease we recorded 978 total hip replacements (THRs) and 538 total knee replacements (TKRs) during a median follow-up time of 15.7 years. The analyses were adjusted for sex, age, BMI (body mass index), smoking, physical activity and diabetes. We did not find any association between TSH (thyroid stimulating hormone) and THR or TKR due to osteoarthritis. Neither were changes in TSH over time, or overt hypo- or hyperthyroidism, associated with incidence of THR or TKR. No association was found between thyroid function and hip or knee joint replacement due to osteoarthritis.Funding Information
- Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU)
- Dr. Egil Kjeldaas foundation (Lege Egil Kjeldaas legat)
- the Norwegian Orthopaedic Association
- Levanger Hospital, Nord-Trøndelag Hospital Trust
This publication has 37 references indexed in Scilit:
- Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010The Lancet, 2013
- Thyroid hormone and obesityCurrent Opinion in Endocrinology, Diabetes and Obesity, 2012
- Thyroid Hormone Actions in Cartilage and BoneEuropean Thyroid Journal, 2012
- Total hip replacement in young adults with hip dysplasiaActa Orthopaedica, 2011
- Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibilityAnnals Of The Rheumatic Diseases, 2010
- Use of the Thyroid Hormone Analogue Eprotirome in Statin-Treated DyslipidemiaThe New England Journal of Medicine, 2010
- Thyroid Function and Cancer Risk: A Prospective Population StudyCancer Epidemiology, Biomarkers & Prevention, 2009
- Reliability and validity of self-reported physical activity in the Nord-Trøndelag Health Study (HUNT 2)European Journal of Epidemiology, 2007
- Registration completeness in the Norwegian Arthroplasty RegisterActa Orthopaedica, 2006
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986