The Role of Antioxidant Micronutrients in the Prevention of Diabetic Complications
- 1 January 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Treatments in Endocrinology
- Vol. 3 (1), 41-52
- https://doi.org/10.2165/00024677-200403010-00005
Abstract
Diabetes mellitus is associated with an increased production of reactive oxygen species and a reduction in antioxidant defenses. This leads to oxidative stress, which is partly responsible for diabetic complications. Tight glycemic control is the most effective way of preventing or decreasing these complications. Nevertheless, antioxidant micronutrients can be proposed as adjunctive therapy in patients with diabetes. Indeed, some minerals and vitamins are able to indirectly participate in the reduction of oxidative stress in diabetic patients by improving glycemic control and/or are able to exert antioxidant activity. This article reviews the use of minerals (vanadium, chromium, magnesium, zinc, selenium, copper) and vitamins or cofactors (tocopherol [vitamin E], ascorbic acid [vitamin C], ubidecarenone [ubiquinone; coenzyme Q], nicotinamide, riboflavin, thioctic acid [lipoic acid], flavonoids) in diabetes, with a particular focus on the prevention of diabetic complications. Results show that dietary supplementation with micronutrients may be a complement to classical therapies for preventing and treating diabetic complications. Supplementation is expected to be more effective when a deficiency in these micronutrients exists. Nevertheless, many clinical studies have reported beneficial effects in individuals without deficiencies, although several of these studies were short term and had small sample sizes. However, a randomized, double-blind, placebo-controlled, multicenter trial showed that thioctic acid at an oral dosage of 800 mg/day for 4 months significantly improved cardiac autonomic neuropathy in type 2 diabetic patients. Above all, individuals with diabetes should be educated about the importance of consuming adequate amounts of vitamins and minerals from natural food sources, within the constraints of recommended sugar and carbohydrate intake.Keywords
This publication has 99 references indexed in Scilit:
- Magnesium, Potassium and Zinc Deficiency in Subjects with Type II Diabetes MellitusActa Medica Scandinavica, 2009
- Preparation and characterization of vanadyl complexes with bidentate maltol-type ligands; in vivo comparisons of anti-diabetic therapeutic potentialJBIC Journal of Biological Inorganic Chemistry, 2003
- Low serum magnesium levels and metabolic syndromeActa Diabetologica, 2002
- Double‐blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in Type 2 diabetic patientsDiabetic Medicine, 2001
- Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non—insulin-dependent diabetes mellitusMetabolism, 1996
- Increased potency of vanadium using organic ligandsMolecular and Cellular Biochemistry, 1995
- The relationship between insulin and vanadium metabolism in insulin target tissuesMolecular and Cellular Biochemistry, 1995
- Studies of Vanadyl Sulfate as a Glucose-Lowering Agent in STZ-Diabetic RatsBiochemical and Biophysical Research Communications, 1993
- Homologous physiological effects of phenformin and chromium picolinateMedical Hypotheses, 1993
- Nicotinamide Increases C-peptide Secretion in Patients with Recent Onset Type 1 DiabetesDiabetic Medicine, 1989