A very high yielding and facile alkaline earth metals homogeneous catalysis of Biginelli reaction: an improved protocol
Open Access
- 1 June 2008
- journal article
- research article
- Published by Taylor & Francis Ltd in Green Chemistry Letters and Reviews
- Vol. 1 (2), 133-139
- https://doi.org/10.1080/17518250802342527
Abstract
A high yielding and facile Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones, using inexpensive and available alkaline earth metal chlorides (MgCl2, CaCl2, SrCl2 and BaCl2) and acetic acid as the solvent in a homogeneous catalytic reaction, is reported.Keywords
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