Non–HDL Cholesterol, Apolipoproteins A-I and B100, Standard Lipid Measures, Lipid Ratios, and CRP as Risk Factors for Cardiovascular Disease in Women

Abstract

While measurement of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) are recommended in most current cardiovascular screening algorithms,^1-3 several investigations have suggested that superior risk prediction might be achieved by alternatively measuring apolipoproteins B₁₀₀ and A-I.^4-8 At the same time, recent guidelines have emphasized the importance of non–HDL-C as a predictor of cardiovascular risk,¹ while others have strongly advocated use of specific lipid ratios such as total cholesterol to HDL-C, LDL-C to HDL-C, apolipoprotein B₁₀₀ to apolipoprotein A-I, and apolipoprotein B₁₀₀ to HDL-C.^9-12