MicroRNAs in pancreas development
- 28 August 2012
- journal article
- review article
- Published by Wiley in Diabetes, Obesity and Metabolism
- Vol. 14 (s3), 22-28
- https://doi.org/10.1111/j.1463-1326.2012.01656.x
Abstract
The development of the pancreas is a tightly regulated process involving extensive morphogenesis, proliferation and differentiation of the epithelium. The finely orchestrated control of gene expression plays a key role in this equilibrium by coordinating the expression of selected gene products at specific moments and in precise locations. MicroRNAs (miRNAs) are small non-coding RNAs that function in general as negative regulators of gene transcripts by interacting with the three prime untranslated regions (3'UTR) of target mRNAs. MiRNAs modulate the expression of numerous target genes that are involved in a variety of cellular systems. Hence the homeostatic control of miRNA biosynthesis and activity is important for the fine-tuning of many physiological processes such as cell differentiation, cell proliferation and organ development. In the present review, we will focus on the implication of these miRNAs on the development of the pancreas and more specifically on beta-cells.This publication has 67 references indexed in Scilit:
- Mammalian microRNAs predominantly act to decrease target mRNA levelsNature, 2010
- Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiationMechanisms of Development, 2009
- Origins and Mechanisms of miRNAs and siRNAsCell, 2009
- Biogenesis of small RNAs in animalsNature Reviews Molecular Cell Biology, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in DrosophilaCell, 2007
- Intronic microRNA precursors that bypass Drosha processingNature, 2007
- DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewalNature Genetics, 2007
- TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencingNature, 2005
- A pancreatic islet-specific microRNA regulates insulin secretionNature, 2004