Safety, Tolerability, and Efficacy of High-Frequency Chest Wall Oscillation in Pediatric Patients With Cerebral Palsy and Neuromuscular Diseases: An Exploratory Randomized Controlled Trial
- 31 March 2010
- journal article
- clinical trial
- Published by SAGE Publications in Journal of Child Neurology
- Vol. 25 (7), 815-821
- https://doi.org/10.1177/0883073809350223
Abstract
Airway secretions and infections are common in cerebral palsy and neuromuscular diseases. Chest physiotherapy is standard therapy but effort is substantial. High-frequency chest wall oscillation is used in cystic fibrosis but tolerability and safety data in cerebral palsy and neuromuscular disease are limited. A prospective, randomized, controlled trial of high-frequency chest wall oscillation and standard chest physiotherapy was performed in participants with neuromuscular disease or cerebral palsy. Outcome measures included respiratory-related hospitalizations, antibiotic therapy, chest radiographs, and polysomnography. Care-givers were questioned regarding therapy adherence. A total of 28 participants enrolled, 23 completed (12 chest physiotherapy, mean study period 5 months). No adverse outcomes were reported. Adherence to prescribed regimen was higher with high-frequency chest wall oscillation (P = .036). Our data suggest safety, tolerability, and better compliance with high-frequency chest wall oscillation. Improvement in airway clearance may help prevent hospitalizations. Larger controlled trials are required to confirm these results.Keywords
This publication has 13 references indexed in Scilit:
- Practice Parameter: Diagnostic assessment of the child with cerebral palsy [RETIRED]Neurology, 2004
- Disorders of the Respiratory MusclesAmerican Journal of Respiratory and Critical Care Medicine, 2003
- Respiratory problems in children with neurological impairmentArchives of Disease in Childhood, 2003
- The Assessment and Management of the Respiratory Complications of Pediatric Neuromuscular DiseasesClinical Pediatrics, 2002
- Amyotrophic lateral sclerosis: evaluation and treatment of respiratory impairmentAmyotrophic Lateral Sclerosis, 2002
- Pulmonary manifestations of neuromuscular disease with special reference to Duchenne muscular dystrophy and spinal muscular atrophyPediatric Pulmonology, 2000
- Respiratory aspects of neurological diseaseJournal of Neurology, Neurosurgery & Psychiatry, 1999
- Cardiac Involvement in Werdnig-Hoffmann’s Spinal Muscular At rophyCardiology, 1999
- Fortnightly review: The muscular dystrophiesBMJ, 1998
- Comparison of high frequency chest compression and conventional chest physiotherapy in hospitalized patients with cystic fibrosis.American Journal of Respiratory and Critical Care Medicine, 1994