Intravenous lidocaine for fibromyalgia syndrome: an open trial
- 5 March 2009
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Clinical Rheumatology
- Vol. 28 (7), 853-855
- https://doi.org/10.1007/s10067-009-1137-8
Abstract
Fibromyalgia is a disorder characterized by chronic widespread pain. In this study, we investigated the effect of intravenous infusions of lidocaine in pain and quality of life of patients with fibromyalgia. Twenty-three consecutive patients were included in the study, which consisted on five sequential intravenous 2% lidocaine infusions with rising dosages (2–5 mg/kg, days 1–5). Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire, and a visual analog scale (VAS) for pain were applied before the first lidocaine infusion, immediately after the fifth infusion and 30 days after the fifth infusion. A significant improvement was observed in the FIQ scores after the fifth infusion (73.52 ± 16.56 vs 63.29 ± 21.21, p = 0.02), which was maintained after 30 days (73.52 ± 16.56 vs 63.85 ± 24.59, p = 0.04). Similar results were seen concerning the VAS: 8.19 ± 1.76 vs 6.84 ± 2.44, p = 0.01 and 8.19 ± 1.76 vs 7.17 ± 2.35, p = 0.05, respectively. Intravenous lidocaine infusions are safe and effective in the management of fibromyalgia.This publication has 12 references indexed in Scilit:
- Update on Fibromyalgia TherapyThe American Journal of Medicine, 2008
- The Role of Sodium Channels in Chronic Inflammatory and Neuropathic PainThe Journal of Pain, 2006
- Systemic Administration of Local Anesthetics to Relieve Neuropathic Pain: A Systematic Review and Meta-AnalysisAnesthesia & Analgesia, 2005
- Neurobiology of fibromyalgia syndrome.2005
- The relationship of fibromyalgia to neuropathic pain syndromes.2005
- Does intravenous lidocaine reduce fibromyalgia pain?: A randomized, double-blind, placebo controlled cross-over studyThe Pain Clinic, 2000
- Will ion-channel blockers be useful for management of nonneuropathic pain?The Journal of Pain, 2000
- Low-dose lidocaine reduces secondary hyperalgesia by a central mode of actionPain, 2000
- Intravenous lignocaine in the management of primary fibromyalgia syndrome.1995
- Pain Analysis in Patients with Fibromyalgia:Effects of intravenous morphine, lidocaine, and ketamineScandinavian Journal of Rheumatology, 1995