Cyclooxygenase inhibitory properties ofnor-neolignans fromStyrax pohlii
- 29 March 2012
- journal article
- research article
- Published by Taylor & Francis Ltd in Natural Product Research
- Vol. 26 (24), 2323-2329
- https://doi.org/10.1080/14786419.2012.671320
Abstract
Chemical investigation of the n-hexane and EtOAc fractions of the ethanolic extract from Styrax pohlii (Styracaceae) aerial parts resulted in the isolation of the benzofuran nor-neolignan derivatives egonol (1), homoegonol (2), homoegonol gentiobioside (3), homoegonol glucoside (4) and egonol gentiobioside (5). This is the first report of compounds 1–5 in S. pohlii. Compounds 1–5, the acetyl derivatives 1 a and 2 a, the ethanolic extract (EE), the n-hexane fraction (HF) and EtOAc fraction (EF) were tested for their inhibitory activities against COX-1 and COX-2. The results showed that EE, HF, EF and compounds 1–5 and 1 a–2 a shown weak to moderate inhibition of COX-1 and COX-2. Among the assayed nor-neolignans, 4 gave a COX-1 inhibition of 35.7% at 30 µM. Compound 5 displayed a COX-2 inhibition of 19.7% at 30 µM.This publication has 22 references indexed in Scilit:
- Derivatives of schisandrin with increased inhibitory potential on prostaglandin E2 and leukotriene B4 formation in vitroBioorganic & Medicinal Chemistry, 2010
- Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory and antioxidant effects of Dysophylla stellata Benth.Fitoterapia, 2010
- COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignansBioorganic & Medicinal Chemistry Letters, 2009
- Synthesis and antibacterial activity of egonol derivativesBioorganic & Medicinal Chemistry, 2008
- Analgesic and anti-inflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) PedersenJournal of Ethnopharmacology, 2005
- Anti-Complement Activity of Norlignans and Terpenes from the Stem Bark ofStyrax japonicaPlanta Medica, 2004
- COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expressionProceedings of the National Academy of Sciences of the United States of America, 2002
- Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cellsLife Sciences, 1994
- Four benzofuran glycosides from Styrax officinalisPhytochemistry, 1980
- Egonol. Spectrometric properties and derivativesCanadian Journal of Chemistry, 1967