Muscle Coenzyme Q10 Level in Statin-Related Myopathy
Open Access
- 1 November 2005
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 62 (11), 1709-1712
- https://doi.org/10.1001/archneur.62.11.1709
Abstract
Statin drugs (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are widely prescribed drugs that reduce blood cholesterol levels by inhibiting the synthesis of mevalonate, a critical intermediary in the cholesterol pathway. Statin drug therapy has been associated with a variety of muscle complaints, ranging from myalgia and cramps to exercise intolerance, weakness, and, occasionally, acute muscle breakdown with myoglobinuria.1,2 Serum creatine kinase (CK) levels are elevated in all of these conditions.2 It is curious that muscle symptoms and high serum CK levels often persist even after statin drug withdrawal.2Keywords
This publication has 15 references indexed in Scilit:
- Molecular clues into the pathogenesis of statin‐mediated muscle toxicityMuscle & Nerve, 2005
- Statins induce apoptosis in rat and human myotube cultures by inhibiting protein geranylgeranylation but not ubiquinoneToxicology and Applied Pharmacology, 2004
- Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at Risk for Cardiovascular Disease and StrokeArchives of Neurology, 2004
- Primary coenzyme Q10 deficiency and the brainBioFactors, 2003
- Lack of apoptosis in patients with progressive external ophthalmoplegia and mutated adenine nucleotide translocator-1 geneMuscle & Nerve, 2002
- Myopathy and rhabdomyolysis with lipid-lowering drugsToxicology Letters, 2002
- Retrospective study of a large population of patients affected with mitochondrial disorders: clinical, morphological and molecular genetic evaluation.Zeitschrift für Neurologie, 2001
- Coenzyme Q 10 reverses pathological phenotype and reduces apoptosis in familial CoQ 10 deficiencyNeurology, 2001
- Mitochondrial encephalomyopathy with coenzyme Q 10 deficiencyNeurology, 1997
- Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy.Proceedings of the National Academy of Sciences, 1989