Effect of Cell Culture Conditions on the Anticytomegalovirus Activity of Maribavir
- 1 July 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (7), 2557-2559
- https://doi.org/10.1128/aac.00207-06
Abstract
The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.Keywords
This publication has 10 references indexed in Scilit:
- Phenotyping of Cytomegalovirus Drug Resistance Mutations by Using Recombinant Viruses Incorporating a Reporter GeneAntimicrobial Agents and Chemotherapy, 2005
- The pleiotropic effects of mTor inhibitors.2004
- Cyclin-Dependent Kinase Activity Is Required at Early Times for Accurate Processing and Accumulation of the Human Cytomegalovirus UL122-123 and UL37 Immediate-Early Transcripts and at Later Times for Virus ProductionJournal of Virology, 2004
- Human Cytomegalovirus Infection Induces Rapamycin-Insensitive Phosphorylation of Downstream Effectors of mTOR KinaseJournal of Virology, 2004
- In Vitro Activities of Benzimidazole d - and l -Ribonucleosides against HerpesvirusesAntimicrobial Agents and Chemotherapy, 2003
- Phase I Dose Escalation Trial Evaluating the Pharmacokinetics, Anti-Human Cytomegalovirus (HCMV) Activity, and Safety of 1263W94 in Human Immunodeficiency Virus-Infected Men with Asymptomatic HCMV SheddingAntimicrobial Agents and Chemotherapy, 2002
- Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l -Riboside with a Unique Mode of ActionAntimicrobial Agents and Chemotherapy, 2002
- Human Cytomegalovirus Up-Regulates the Phosphatidylinositol 3-Kinase (PI3-K) Pathway: Inhibition of PI3-K Activity Inhibits Viral Replication and Virus-Induced SignalingJournal of Virology, 2001
- Inhibition of Cytomegalovirus in vitro and in vivo by the Experimental Immunosuppressive Agent LeflunomideIntervirology, 1999
- Inhibition of Cellular Cdk2 Activity Blocks Human Cytomegalovirus ReplicationVirology, 1997