Repolarization Dynamics in Patients with Idiopathic Ventricular Fibrillation
- 1 June 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Cardiovascular Pharmacology
- Vol. 45 (6), 545-549
- https://doi.org/10.1097/01.fjc.0000159660.16793.84
Abstract
The electrocardiographic parameters relating occurrence of ventricular fibrillation (VF) episodes in patients with idiopathic VF (IVF) are still unknown. The aim of this study was to clarify efficacy of pharmacological therapy in patients with IVF with respect to repolarization dynamics. The study group consisted of 8 men (age 43.6 ± 9.1 years) with IVF (Brugada type 5 patients, prominent J wave in the inferior leads 3 patients) who had documented spontaneous episodes of VF, 7 of whom had implantable cardioverter defibrillators. The relation between QT and RR interval was analyzed from 24-hour Holter ECG using an automatic analyzing system before and after pharmacological therapy (bepridil 5 and disopyramide 3). From QT-RR linear regression lines, QT intervals were determined at RR intervals of 0.6 second [QT(0.6)], 1.0 second [QT(1.0)], and 1.2 seconds [QT(1.2)]. Pharmacological therapy increased the slope of QT-RR regression line from 0.105 ± 0.020 to 0.144 ± 0.037 (PKeywords
This publication has 18 references indexed in Scilit:
- Is idiopathic ventricular fibrillation a short QT syndrome? Comparison of QT intervals of patients with idiopathic ventricular fibrillation and healthy controlsHeart Rhythm, 2004
- Efficacy of Quinidine in High-Risk Patients With Brugada SyndromeCirculation, 2004
- Repolarization Abnormality in Idiopathic Ventricular Fibrillation:Journal of Cardiovascular Electrophysiology, 2004
- Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non–SCN5A-related patientsJournal of the American College of Cardiology, 2002
- Ventricular Fibrillation in a Patient with Prominent J (Osborn) Waves and ST Segment Elevation in the Inferior Electrocardiographic Leads:Journal of Cardiovascular Electrophysiology, 2000
- The Brugada syndrome: clinical, electrophysiologic and genetic aspectsJournal of the American College of Cardiology, 1999
- Genetic basis and molecular mechanism for idiopathic ventricular fibrillationNature, 1998
- Arrhythmogenic Marker for the Sudden Unexplained Death Syndrome in Thai MenCirculation, 1997
- Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndromeJournal of the American College of Cardiology, 1992
- Idiopathic ventricular fibrillationAmerican Heart Journal, 1990