Long-term Follow-up of Corneal Collagen Cross-linking for Keratoconus—The Cretan Study
- 1 October 2014
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Cornea
- Vol. 33 (10), 1071-1079
- https://doi.org/10.1097/ico.0000000000000248
Abstract
Purpose: The aim of this study was to present the long-term results of corneal collagen cross-linking (CXL) in patients with keratoconus. Methods: In this prospective, interventional case series, patients with progressive keratoconus underwent CXL treatment according to the Dresden protocol. Visual, refractive, and topographic outcomes along with endothelial cell density were evaluated preoperatively and at 1, 2, 3, 4, and 5 years postoperatively. Results: Twenty-one patients (25 eyes) were enrolled. The mean follow-up was 43.7 ± 12.2 (range, 24–60) months. Logarithm of the minimum angle of resolution (logMAR) mean uncorrected visual acuity and the mean best spectacle-corrected visual acuity improved significantly from 0.92 ± 0.54 and 0.29 ± 0.21 preoperatively to 0.63 ± 0.41 (P = 0.010) and 0.18 ± 0.18 (P = 0.011), respectively, at the last follow-up. Mean steep and mean flat keratometry readings reduced significantly from 52.53 ± 6.95 diopters (D) and 48.11 ± 5.98 D preoperatively to 49.10 ± 4.50 D (P < 0.001) and 45.58 ± 3.81 D (P = 0.001), respectively, at the last follow-up. The mean endothelial cell density was 2708 ± 302 cells per square millimeter preoperatively and did not change significantly (P > 0.05) at any postoperative interval (2593 ± 258 cells/mm2 at the last follow-up; P = 0.149). Conclusions: CXL seems to be effective and safe in halting progression of keratoconus over a long-term follow-up period up to 5 years postoperatively.Keywords
This publication has 19 references indexed in Scilit:
- Long-term follow-up of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linking to halt the progression of keratoconusBritish Journal of Ophthalmology, 2013
- Combined Transepithelial Phototherapeutic Keratectomy and Corneal Collagen Cross-Linking for Progressive KeratoconusOphthalmology, 2012
- Long-term Results of Riboflavin Ultraviolet A Corneal Collagen Cross-linking for Keratoconus in Italy: The Siena Eye Cross StudyAmerican Journal of Ophthalmology, 2010
- Intraoperative and Postoperative Effects of Corneal Collagen Cross-linking on Progressive KeratoconusAmerican Journal of Ophthalmology, 2009
- Refractive, Topographic, Tomographic, and Aberrometric Analysis of Keratoconic Eyes Undergoing Corneal Cross-LinkingOphthalmology, 2009
- Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: Long-term resultsJournal of Cataract & Refractive Surgery, 2008
- Long-term Follow-up of Intacs in KeratoconusAmerican Journal of Ophthalmology, 2007
- Extended Long-term Outcomes of Penetrating Keratoplasty for KeratoconusOphthalmology, 2006
- Riboflavin/ultraviolet-a–induced collagen crosslinking for the treatment of keratoconusAmerican Journal of Ophthalmology, 2003
- KeratoconusSurvey of Ophthalmology, 1998