The Temporolimbic System Theory of Positive Schizophrenic Symptoms

Abstract

This article proposes that subtle structural and functional disturbance of limbic key structures in the medial temporal lobe—especially of the left hippocampal formation and parahippocampal gyrus—can explain the so-called positive symptoms of schizophrenia. After presenting pathophysiological considerations linking limbic dysfunction to schizophrenia, the article reviews evidence from structural, biochemical, and functional studies supporting the theory. Also discussed here are neurodevelopmental and laterality aspects, as well as predictions, questions, and future tasks derived from the theory.