An imbalance between stellate cells and γδT cells contributes to hepatocellular carcinoma aggressiveness and recurrence
- 24 July 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Hepatology International
- Vol. 13 (5), 631-640
- https://doi.org/10.1007/s12072-019-09969-w
Abstract
The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of these patients have not yet been investigated. The aim of this study was to elucidate the prognostic value of these cells in HCC.Keywords
Funding Information
- Chongqing Science and Technology Commission (cstc2017jcyjBX0010, cstc2018jcyjAX0162)
- Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN201800416)
This publication has 20 references indexed in Scilit:
- The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent mannerNature Communications, 2017
- Proteinase-activated receptor 2 (PAR2) in hepatic stellate cells – evidence for a role in hepatocellular carcinoma growth in vivoMolecular Cancer, 2016
- γδ T cells in cancerNature Reviews Immunology, 2015
- The functional impairment of HCC-infiltrating γδ T cells, partially mediated by regulatory T cells in a TGFβ- and IL-10-dependent mannerJournal of Hepatology, 2013
- Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular CarcinomaGastroenterology, 2013
- High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinomaJournal of Experimental & Clinical Cancer Research, 2013
- The activity of γδ T cells against paediatric liver tumour cells and spheroids in cell cultureLiver International, 2012
- Expression of TREM‐1 in hepatic stellate cells and prognostic value in hepatitis B‐related hepatocellular carcinomaCancer Science, 2012
- The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targetsSeminars in Cancer Biology, 2011
- γδ T cell effector functions: a blend of innate programming and acquired plasticityNature Reviews Immunology, 2010