Sensitivity of the Hypothermic Myocardium to Calcium
- 1 March 1957
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 5 (2), 196-201
- https://doi.org/10.1161/01.res.5.2.196
Abstract
The susceptibility of the dog heart to ventricular fibrillation (VF) induced by CaCl2 infusions is several fold greater in hypothermia than in normothermia, i.e., both the amount of CaCl2 infused and the terminal plasma levels are found to be less in hypothermia. Dogs rendered hypercalcemic prior to hypothermia induction also succumb to ventricular fibrillation, and at relatively high heart temperatures (22-27 C.), whereas those rendered hypocalcemic by Na-EDTA infusions succumb to asystole at much lower temperatures (14-18 C.). The calcium sensitivity is not pH dependent either at normal or low temperatures.Keywords
This publication has 2 references indexed in Scilit:
- CARDIOVASCULAR RESPONSE OF THE DOG TO IMMERSION HYPOTHERMIAAmerican Journal of Physiology-Legacy Content, 1950
- ELECTROCARDIOGRAPHIC CHANGES AND CONCENTRATION OF CALCIUM IN SERUM FOLLOWING INTRAVENOUS INJECTION OF CALCIUM CHLORIDEAmerican Journal of Physiology-Legacy Content, 1938