Anterior craniofacial resection for malignant paranasal tumors: A monoinstitutional experience of 366 cases
- 5 April 2011
- journal article
- research article
- Published by Wiley in Head & Neck
- Vol. 34 (1), 78-87
- https://doi.org/10.1002/hed.21685
Abstract
Background The purpose of this study was to evaluate the results of a mono‐institutional series of patients treated with anterior craniofacial resection for malignant paranasal sinus tumors. Methods We analyzed all patients with malignant paranasal sinus tumors treated with anterior craniofacial resection at our institution between 1987 and 2007. All tumors were classified according to both the American Joint Committee on Cancer (AJCC)‐2002 and the Istituto Nazionale Tumori (INT) classifications. Results The sample included 366 patients. There was intraorbital spread in 108 cases. The skull base was eroded in 127 patients, with dura or brain involvement in 93 patients. The 10‐year disease‐specific survival was 53.1%. Histologic subtype, INT stage, surgical margins, and postsurgical radiotherapy were significant, independent predictors for both local relapse and disease‐specific survival (DSS). The AJCC‐2002 classification was not significant when tested in place of INT stage. Conclusion Our data indicated that craniofacial resection and postsurgical radiotherapy remain the primary option for malignant tumors involving the anterior skull base. © 2011 Wiley Periodicals, Inc. Head Neck, 2012Keywords
This publication has 26 references indexed in Scilit:
- Surgery for Malignant Maxillary Tumors Involving the Middle Cranial FossaJournal of Neurological Surgery Part B: Skull Base, 2009
- Role of endoscopic surgery in the management of selected malignant epithelial neoplasms of the naso‐ethmoidal complexHead & Neck, 2007
- Craniofacial resection for tumors of the nasal cavity and paranasal sinuses: A 25-year experienceHead & Neck, 2006
- Which classification for ethmoid malignant tumors involving the anterior skull base?Head & Neck, 2004
- Craniofacial surgery for malignant skull base tumorsCancer, 2003
- Anterior skull base surgery for malignant tumors: A multivariate analysis of 27 years of experienceHead & Neck, 2003
- Combined Anterior Craniofacial Resection for Tumors Involving the Cribriform Plate: Early Postoperative Complications and Technical ConsiderationsNeurosurgery, 2000
- Flexible regression models with cubic splinesStatistics in Medicine, 1989
- A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing RiskThe Annals of Statistics, 1988
- Partial residuals for the proportional hazards regression modelBiometrika, 1982