Treatment of Severe Cold Contact Urticaria with Omalizumab: Case Reports
Open Access
- 1 January 2012
- journal article
- Published by S. Karger AG in Case Reports in Dermatology
- Vol. 4 (3), 275-280
- https://doi.org/10.1159/000346284
Abstract
We report 2 patients with cold urticaria with different response to treatment with omalizumab (Xolair®). Cold contact urticaria (CCU) is a common subtype of physical urticaria. It is characterized by the development of wheal and/or angioedema within minutes after cold contact. Clinical manifestation of CCU can range from mild, localized whealing to life-threatening anaphylactic shock reactions. Omalizumab has been described to be useful in cases of chronic urticaria and may be an interesting option for treatment of CCU. We describe one patient with significant and long-lasting improvement of symptoms and one without any improvement after anti-immunoglobulin E therapy. In our case reports, we want to highlight that there is still a small group of patients without benefit from omalizumab treatment. It is necessary to identify this minor subgroup of patients where omalizumab does not represent an effective treatment possibility.Keywords
This publication has 23 references indexed in Scilit:
- Cold Urticaria, Immunodeficiency, and Autoimmunity Related toPLCG2DeletionsThe New England Journal of Medicine, 2012
- A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine–refractory chronic idiopathic urticariaJournal of Allergy and Clinical Immunology, 2011
- Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidaseJournal of Allergy and Clinical Immunology, 2011
- Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City ChildrenThe New England Journal of Medicine, 2011
- Anti-Immunoglobulin E Treatment of Patients with Recalcitrant Physical UrticariaInternational Archives of Allergy and Immunology, 2010
- Efficacy of omalizumab in delayed pressure urticaria: a case reportAllergy, 2009
- Reduced FcεRI-Mediated Release of Asthma-Promoting Cytokines and Chemokines from Human Basophils during Omalizumab TherapyInternational Archives of Allergy and Immunology, 2009
- Cold urticaria; disease course and outcome - an investigation of 85 patients before and after therapyBritish Journal of Dermatology, 2005
- Clinical characteristics of cold-induced systemic reactions in acquired cold urticaria syndromes: Recommendations for prevention of this complication and a proposal for a diagnostic classification of cold urticariaJournal of Allergy and Clinical Immunology, 1986
- Identification of a new physically induced urticaria: cold-induced cholinergic urticariaJournal of Allergy and Clinical Immunology, 1981