Class II Histone Deacetylases: from Sequence to Function, Regulation, and Clinical Implication
Open Access
- 1 April 2005
- journal article
- review article
- Published by Taylor & Francis Ltd in Molecular and Cellular Biology
- Vol. 25 (8), 2873-2884
- https://doi.org/10.1128/mcb.25.8.2873-2884.2005
Abstract
Three fundamental issues in postgenomic biology are (i) how the amino acid sequence of a given human protein pred- icates its structure, function, and regulation; (ii) how a protein is compared to its paralogs, as well as to its orthologs and other homologous proteins in model organisms; and (iii) how related studies contribute to the understanding of human pathology and the development of efficacious diagnostic and therapeutic means. These fascinating issues have inspired us to conduct a comprehensive analysis of information available on class II histone deacetylases (HDACs). In what follows, we will start with a brief description of different classes of HDACs and then compare class II HDACs from yeast and higher organisms in terms of domain organization, function, and regulation. We will also discuss evidence that links class II human HDACs to cardiomyopathy, osteodystrophy, neurodegenerative disorders, and cancer and will propose that, in addition to inhibitors, activators of these HDACs are of potential therapeutic value. DIFFERENT CLASSES OF HDACsKeywords
This publication has 173 references indexed in Scilit:
- Molecular signature of oncogenic ras-induced senescenceOncogene, 2004
- Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Coincides with the Loss of Androgen Sensitivity in Hormone Refractory Cancer of the ProstateEuropean Urology, 2004
- Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cip1 expression in human colon tumor cell linesCarcinogenesis: Integrative Cancer Research, 2004
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 2003
- Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegansBiochemical and Biophysical Research Communications, 2002
- NFAT Signaling: Choreographing the Social Lives of CellsCell, 2002
- Isolation and Characterization of Mammalian HDAC10, a Novel Histone DeacetylasePublished by Elsevier BV ,2002
- A Dynamic Role for HDAC7 in MEF2-mediated Muscle DifferentiationPublished by Elsevier BV ,2001
- Tip60 and HDAC7 Interact with the Endothelin Receptor A and May Be Involved in Downstream SignalingPublished by Elsevier BV ,2001
- HDAC4 deacetylase associates with and represses the MEF2 transcription factorThe EMBO Journal, 1999