Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates
- 1 September 2010
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 137 (17), 2807-2817
- https://doi.org/10.1242/dev.047498
Abstract
The formation of the musculoskeletal system represents an intricate process of tissue assembly involving heterotypic inductive interactions between tendons, muscles and cartilage. An essential component of all musculoskeletal systems is the anchoring of the force-generating muscles to the solid support of the organism: the skeleton in vertebrates and the exoskeleton in invertebrates. Here, we discuss recent findings that illuminate musculoskeletal assembly in the vertebrate embryo, findings that emphasize the reciprocal interactions between the forming tendons, muscle and cartilage tissues. We also compare these events with those of the corresponding system in the Drosophila embryo, highlighting distinct and common pathways that promote efficient locomotion while preserving the form of the organism.Keywords
This publication has 91 references indexed in Scilit:
- Bone Ridge Patterning during Musculoskeletal Assembly Is Mediated through SCX Regulation of Bmp4 at the Tendon-Skeleton JunctionDevelopmental Cell, 2009
- Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctionsDevelopment, 2009
- Transforming Growth Factors β Coordinate Cartilage and Tendon Differentiation in the Developing Limb MesenchymePublished by Elsevier BV ,2009
- Reception of Slit requires only the chondroitin–sulphate-modified extracellular domain of Syndecan at the target cell surfaceProceedings of the National Academy of Sciences of the United States of America, 2009
- TGF-β mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible developmentDevelopmental Biology, 2008
- Structure‐function relationships in tendons: a reviewJournal of Anatomy, 2008
- Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesisThe EMBO Journal, 2006
- Where tendons and ligaments meet bone: attachment sites (‘entheses’) in relation to exercise and/or mechanical loadJournal of Anatomy, 2006
- Developmental regulation of the growth plateNature, 2003
- Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancergenesis, 2002