Hemorrhagic corpus luteum: Clinical management update
Open Access
- 1 December 2020
- journal article
- review article
- Published by Galenos Yayinevi in Journal of Turkish Society of Obstetric and Gynecology
- Vol. 17 (4), 300-309
- https://doi.org/10.4274/tjod.galenos.2020.40359
Abstract
Hemorrhagic corpus luteum (HCL) is an ovarian cyst formed after ovulation and caused by spontaneous bleeding into a corpus luteum (CL) cyst. When HCL rupture happens, a hemoperitoneum results. Clinical symptoms are mainly due to peritoneal irritation by the blood effusion. The differential diagnosis is extensive and standard management is not defined. The authors elaborated a comparison of the differential diagnosis and therapeutic modalities from the laparoscopic approach to nonsurgical, medical options because hemorrhage from HCL is often self-limiting. The authors reviewed all data implicated with the development of HCL, trying to give homogeneity to literature data. The authors analyzed extensive literature data and subdivided the medical approach into many topics. The wait-and-see attitude avoids unnecessary laparoscopic surgery using supportive therapies (antifibrinolytic, analgesics, liquid infusion, transfusions and antibiotic prophylaxis). Surgical therapy: operative management should be laparoscopic, with surgical options such as luteumectomy, ovarian wedge-shaped excision or oophorectomy. Prevention: the possibility to preserve fertility is essential, mainly in patients with bleeding disorders or undergoing anticoagulant therapy; therefore, they need estro-progestinics or GnRH analogues to prevent ovulation and avoid further episodes of HCL. This review will aid physicians in making an early diagnosis of HCL, to avoid unnecessary surgery, and use the most effective treatment.Keywords
This publication has 61 references indexed in Scilit:
- Ruptured Hemorrhagic Ovarian Cyst Presenting as an Incarcerated Inguinal Hernia in an Adult Female: A Rare Clinical Scenario of a Common Surgical EmergencyCase Reports in Emergency Medicine, 2013
- Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trialThe Lancet, 2010
- Sonographic features of tubo-ovarian abscess mimicking an endometrioma and review of cystic adnexal massesJournal of Radiology Case Reports, 2010
- Assessment of cyst content using mean gray value for discriminating endometrioma from other unilocular cysts in premenopausal womenUltrasound in Obstetrics & Gynecology, 2010
- Luteal blood flow and luteal functionJournal of Ovarian Research, 2009
- Changes in blood-flow impedance of the human corpus luteum throughout the luteal phase and during early pregnancyFertility and Sterility, 2008
- Clinical and Laboratory Presentation of Hemorrhagic Corpus LuteumJournal of Gynecologic Surgery, 2008
- Imaging in gynecologyBest Practice & Research Clinical Obstetrics & Gynaecology, 2006
- Recurrent haemoperitoneum in a female patient with type III von Willebrand’s disease responded to administration of oral contraceptiveHaemophilia, 1998
- Prognostic Significance of Morphologic Changes of the Corpus Luteum by Transvaginal Ultrasound in Early Pregnancy MonitoringObstetrics & Gynecology, 1995