Obstructive Sleep Apnea in Family Members
- 2 November 1978
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 299 (18), 969-973
- https://doi.org/10.1056/nejm197811022991801
Abstract
Two sons and their father had severe hypersomnolence and obstructive sleep apnea. A third son, although asymptomatic, was shown to have upper-airway obstruction during sleep. Electromyographic recordings of genioglossus activity in the two symptomatic sons revealed loss of tonic activity in early stages of sleep at times when sleep apnea occurred. The asymptomatic son showed loss of tonic activity during rapid-eye-movement sleep, the sleep period when upper-airway obstruction occurred. Two sudden deaths occurred in this family. A 30-year-old brother died at home while asleep, and a child of the asymptomatic brother died at the age of four months from presumed sudden-infant-death syndrome. Obstructive sleep apnea may have a familial basis; the tongue may be involved in the genesis of upper-airway obstruction during sleep. (N Engl J Med 299:969–973, 1978)Keywords
This publication has 12 references indexed in Scilit:
- State of the Art Sleep and Control of BreathingSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1978
- Laryngeal Abductor Activity during SleepSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1978
- Sleep-induced apnea syndromeAmerican Journal Of Medicine, 1977
- The human tongue during sleep: Electromyographic activity of the genioglossus muscleExperimental Neurology, 1976
- The Sleep Apnea SyndromesAnnual Review of Medicine, 1976
- SnoringElectroencephalography and Clinical Neurophysiology, 1975
- PROLONGED APNEA AND THE SUDDEN INFANT DEATH SYNDROME: CLINICAL AND LABORATORY OBSERVATIONSPEDIATRICS, 1972
- A CLINICAL METHOD FOR ASSESSING THE VENTILATORY RESPONSE TO CARBON DIOXIDEAustralasian Annals of Medicine, 1967
- Polygraphic study of the episodic diurnal and nocturnal (hypnic and respiratory) manifestations of the pickwick syndromeBrain Research, 1966
- Spirometric Studies in Normal SubjectsActa Medica Scandinavica, 1963