Delineating gray and white matter involvement in brain lesions: three-dimensional alignment of functional magnetic resonance imaging and diffusion-tensor imaging
- 1 December 2003
- journal article
- research article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 99 (6), 1018-1027
- https://doi.org/10.3171/jns.2003.99.6.1018
Abstract
The role of functional magnetic resonance (fMR) imaging has become increasingly important in the presurgical mapping of gray matter. Neurosurgical interventions often involve fiber bundles that connect critical functional areas. Recently, diffusion-tensor (DT) imaging has enabled the visualization of fiber bundle direction and integrity, thus providing the ability to delineate clearly white matter from gray matter tissue. The main objective of this study was to improve the presurgical assessment of critical functionality in the vicinity of brain lesions by combining DT and fMR imaging methodologies. Twenty patients with various space-occupying brain lesions underwent imaging for presurgical evaluation of motor and/or somatosensory functions. The authors focus on five patients with diverse space-occupying brain lesions. Diffusion tensor-based fiber tracking and fMR imaging activation maps were superimposed in three dimensions to visualize pyramidal tracts corresponding to motor and somatosensory regional activation. The combination of DT and fMR imaging for presurgical functional brain mapping provides valuable information that cannot be extracted using either method alone. The validity and sensitivity of noninvasive functional mapping for surgical guidance could be improved by considering results obtained with both methods. Furthermore, the use of three-dimensional visualization seems crucial and unique for viewing and understanding the complicated spatial relationship among the lesion, gray matter activation, and white matter fiber bundles.Keywords
This publication has 23 references indexed in Scilit:
- What does fMRI tell us about neuronal activity?Nature Reviews Neuroscience, 2002
- How well do we understand the neural origins of the fMRI BOLD signal?Trends in Neurosciences, 2002
- High b‐value q‐space analyzed diffusion‐weighted MRI: Application to multiple sclerosisMagnetic Resonance in Medicine, 2001
- Neurophysiological investigation of the basis of the fMRI signalNature, 2001
- In vivo fiber tractography using DT-MRI dataMagnetic Resonance in Medicine, 2000
- Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after strokeJournal of Neurology, Neurosurgery & Psychiatry, 2000
- Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: Application to white matter fiber tract mapping in the human brainMagnetic Resonance in Medicine, 1999
- LettersJournal of Neuroimaging, 1997
- Functional magnetic resonance imaging (FMRI) of the human brainJournal of Neuroscience Methods, 1994
- MR diffusion tensor spectroscopy and imagingBiophysical Journal, 1994