Plasmon-Enhanced Fluorescence Biosensors: a Review
Open Access
- 28 December 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Plasmonics
- Vol. 9 (4), 781-799
- https://doi.org/10.1007/s11468-013-9660-5
Abstract
Surfaces of metallic films and metallic nanoparticles can strongly confine electromagnetic field through its coupling to propagating or localized surface plasmons. This interaction is associated with large enhancement of the field intensity and local optical density of states which provides means to increase excitation rate, raise quantum yield, and control far field angular distribution of fluorescence light emitted by organic dyes and quantum dots. Such emitters are commonly used as labels in assays for detection of chemical and biological species. Their interaction with surface plasmons allows amplifying fluorescence signal (brightness) that accompanies molecular binding events by several orders of magnitude. In conjunction with interfacial architectures for the specific capture of target analyte on a metallic surface, plasmon-enhanced fluorescence (PEF) that is also referred to as metal-enhanced fluorescence (MEF) represents an attractive method for shortening detection times and increasing sensitivity of various fluorescence-based analytical technologies. This review provides an introduction to fundamentals of PEF, illustrates current developments in design of metallic nanostructures for efficient fluorescence signal amplification that utilizes propagating and localized surface plasmons, and summarizes current implementations to biosensors for detection of trace amounts of biomarkers, toxins, and pathogens that are relevant to medical diagnostics and food control.Keywords
This publication has 128 references indexed in Scilit:
- Thin Hydrogel Films for Optical Biosensor ApplicationsMembranes, 2012
- Enhancing Single Molecule Imaging in Optofluidics and MicrofluidicsInternational Journal of Molecular Sciences, 2011
- Rapid and Sensitive Detection of Troponin I in Human Whole Blood Samples by Using Silver Nanoparticle Films and Microwave HeatingClinical Chemistry, 2011
- 3D optical Yagi–Uda nanoantenna arrayNature Communications, 2011
- Plasmon-Enhanced Fluorescence from Single Fluorophores End-Linked to Gold NanorodsJournal of the American Chemical Society, 2010
- Time-Resolved Fluorometric Method for One-Step Immunoassays Using Plasmonic NanostructuresThe Journal of Physical Chemistry C, 2009
- Plasmon-controlled fluorescence: a new paradigm in fluorescence spectroscopyThe Analyst, 2008
- Polyelectrolyte Layer-by-Layer Assembly To Control the Distance between Fluorophores and Plasmonic NanostructuresChemistry of Materials, 2007
- Aluminum Nanostructured Films as Substrates for Enhanced Fluorescence in the Ultraviolet-Blue Spectral RegionAnalytical Chemistry, 2007
- S-Layer-Mediated Display of the Immunoglobulin G-Binding Domain of Streptococcal Protein G on the Surface ofCaulobacter crescentus: Development of an Immunoactive ReagentApplied and Environmental Microbiology, 2007