Murine models of pulmonary fibrosis
Top Cited Papers
- 1 February 2008
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Lung Cellular and Molecular Physiology
- Vol. 294 (2), L152-L160
- https://doi.org/10.1152/ajplung.00313.2007
Abstract
Human pulmonary fibrosis is characterized by alveolar epithelial cell injury, areas of type II cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of extracellular matrix proteins. The result is a progressive loss of normal lung architecture and impairment in gas exchange. Pertinent features of the human disease include temporal heterogeneity of the fibrotic lesions, progressive nature of the disease, development of fibrotic foci, and in some patients, a rapid worsening of symptoms known as an acute exacerbation. No current animal model recapitulates all of these cardinal manifestations of the human disease. However, investigations using murine models have led to the identification of many pathological cells and mediators that are believed to be important in human disease as well. In this review, we will summarize the characteristics, advantages, and disadvantages of many of the currently utilized murine models of pulmonary fibrosis.Keywords
This publication has 76 references indexed in Scilit:
- Acute Exacerbations of Idiopathic Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Semaphorin 7A plays a critical role in TGF-β1–induced pulmonary fibrosisThe Journal of Experimental Medicine, 2007
- Therapeutic Targeting of CC Ligand 21 or CC Chemokine Receptor 7 Abrogates Pulmonary Fibrosis Induced by the Adoptive Transfer of Human Pulmonary Fibroblasts to Immunodeficient MiceThe American Journal of Pathology, 2007
- Readministration of helper-dependent adenovirus to mouse lungGene Therapy, 2006
- Prolonged Transgene Expression in Cotton Rat Lung with Recombinant Adenoviruses Defective in E2aHuman Gene Therapy, 1994
- Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase familyBiochemistry, 1989
- The mechanism of the bleomycin-induced cleavage of DNABiochemical and Biophysical Research Communications, 1977
- A role for ferrous ion and oxygen in the degradation of DNA by bleomycinBiochemical and Biophysical Research Communications, 1976
- Regulation of prostaglandin metabolism: Activation of 15-hydroxyprostaglandin dehydrogenase by chlorpromazine and imipramine related drugsBiochemical and Biophysical Research Communications, 1976