Detection of occult lung impairment in welders by induced sputum particles and breath oxidation
- 5 May 2008
- journal article
- research article
- Published by Wiley in American Journal of Industrial Medicine
- Vol. 51 (7), 503-511
- https://doi.org/10.1002/ajim.20586
Abstract
Background We evaluated particulate matter in combined induced sputum (IS) and oxidation in exhaled breath condensate (EBC) to test whether underlying inflammatory changes are present in asymptomatic welders. Methods Thirty welders from the Israel Defense Forces exposed to aluminum/iron (Group 1) or to cadmium/chromium/iron/lead/nickel (Group 2, N = 16) and 27 non-exposed administrators were studied. IS was recovered, particle size distribution, hydrogen peroxide and pH were measured, and exhaled breath condensate was collected. Results Group 2 had a higher % neutrophils than all other participants (P = 0.0001) and a higher % particles >2 µm in diameter (P = 0.0017). Percent particles and years of exposure highly correlated (P = 0.051). All welders EBC samples had higher concentrations of hydrogen peroxide than controls (P = 0.0001). pH was lower only for Group 2 (P = 0.0001). Conclusions Combined IS and EBC measurements detect underlying inflammation in airways of asymptomatic welders. It emerged that airway inflammation is present in asymptomatic welders, and that the particle burden, inflammatory cells, and level of oxidative stress are a function of the type and the duration of welding. Am. J. Ind. Med. 51:503–511, 2008.Keywords
This publication has 42 references indexed in Scilit:
- Factors Affecting Magnetic Retention of Particles in the Upper Airways: An In Vitro and Ex Vivo StudyJournal of Aerosol Medicine, 2006
- Pulmonary function abnormalities and airway irritation symptoms of metal fumes exposure on automobile spot weldersAmerican Journal of Industrial Medicine, 2006
- Inflammatory responses to the occupational inhalation of metal fumeEuropean Respiratory Journal, 2006
- Induced Sputum Assessment in New York City Firefighters Exposed to World Trade Center DustEnvironmental Health Perspectives, 2004
- Pulmonary Responses to Welding Fumes: Role of Metal ConstituentsJournal of Toxicology and Environmental Health, Part A, 2004
- Two year follow up of pulmonary function values among welders in New ZealandOccupational and Environmental Medicine, 1999
- Airway Reactivity in WeldersJournal of Occupational and Environmental Medicine, 1996
- Asthma, lung function, and bronchial responsiveness in weldersAmerican Journal of Industrial Medicine, 1994
- The Evolving Concept of the Healthy Worker Survivor EffectEpidemiology, 1994
- Use of induced sputum cell counts to investigate airway inflammation in asthma.Thorax, 1992