PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial
- 1 October 2014
- journal article
- research article
- Published by Elsevier BV in The Lancet
- Vol. 385 (9965), 331-340
- https://doi.org/10.1016/s0140-6736(14)61399-4
Abstract
No abstract availableKeywords
Funding Information
- AstraZeneca
- Meso Scale Diagnostics
- Genzyme
- Otsuka America
- Merck
- Bayer HealthCare
- Novartis
- Novo Nordisk
- Pfizer
- Ipsen
- AbbVie
- Bristol-Myers Squibb
- Eli Lilly and Company
- Abbott Laboratories
- Amgen
- Sanofi
This publication has 24 references indexed in Scilit:
- Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The NetherlandsAtherosclerosis, 2010
- Efficacy of statins in familial hypercholesterolaemia: a long term cohort studyBMJ, 2008
- Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry studyEuropean Heart Journal, 2008
- Update and Analysis of the University College London Low Density Lipoprotein Receptor Familial Hypercholesterolemia DatabaseAnnals of Human Genetics, 2008
- Further reduction of low-density lipoprotein cholesterol and C-reactive protein with the addition of ezetimibe to maximum-dose rosuvastatin in patients with severe hypercholesterolemiaJournal of Clinical Lipidology, 2007
- Familial Hypercholesterolemia and Coronary Heart Disease: A HuGE Association ReviewAmerican Journal of Epidemiology, 2004
- Mutations in PCSK9 cause autosomal dominant hypercholesterolemiaNature Genetics, 2003
- Molecular genetics of the LDL receptor gene in familial hypercholesterolemiaHuman Mutation, 1992
- Risk of fatal coronary heart disease in familial hypercholesterolaemia. Scientific Steering Committee on behalf of the Simon Broome Register Group.BMJ, 1991
- A sharper Bonferroni procedure for multiple tests of significanceBiometrika, 1988