Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
- 21 April 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 288 (5465), 522-527
- https://doi.org/10.1126/science.288.5465.522
Abstract
Major histocompatibility complex class II (MHC II) molecules capture peptides within the endocytic pathway to generate T cell receptor (TCR) ligands. Immature dendritic cells (DCs) sequester intact antigens in lysosomes, processing and converting antigens into peptide–MHC II complexes upon induction of DC maturation. The complexes then accumulate in distinctive, nonlysosomal MHC II + vesicles that appear to migrate to the cell surface. Although the vesicles exclude soluble lysosomal contents and antigen-processing machinery, many contain MHC I and B7 costimulatory molecules. After arrival at the cell surface, the MHC and costimulatory molecules remain clustered. Thus, transport of peptide–MHC II complexes by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules for T cell contact.Keywords
This publication has 26 references indexed in Scilit:
- The Immunological Synapse: A Molecular Machine Controlling T Cell ActivationScience, 1999
- CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULESAnnual Review of Immunology, 1997
- Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.The Journal of cell biology, 1996
- B lymphocytes secrete antigen-presenting vesicles.The Journal of Experimental Medicine, 1996
- Human Resident Langerhans Cells Display a Lysosomal compartment Enriched in MHC Class IIJournal of Investigative Dermatology, 1994
- Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytesNature, 1994
- Assembly, Transport, and Function of MHC Class II MoleculesAnnual Review of Immunology, 1994
- Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.The Journal of Experimental Medicine, 1992
- Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells.The Journal of cell biology, 1992
- Glycoproteins of the lysosomal membrane.The Journal of cell biology, 1985