Repeat Traumatic Brain Injury in the Juvenile Rat Is Associated with Increased Axonal Injury and Cognitive Impairments
- 8 September 2010
- journal article
- research article
- Published by S. Karger AG in Developmental Neuroscience
- Vol. 32 (5-6), 510-518
- https://doi.org/10.1159/000316800
Abstract
Among the enormous population of head-injured children and young adults are a growing subpopulation who experience repeat traumatic brain injury (RTBI). The most common cause of RTBI in this age group is sports-related concussions, and athletes who have experienced a head injury are at greater risk for subsequent TBI, with consequent long-term cognitive dysfunction. While several animal models have been proposed to study RTBI, they have been shown to either produce injuries too severe, were conducted in adults, involved craniotomy, or failed to show behavioral deficits. A closed head injury model for postnatal day 35 rats was established, and single and repeat TBI (1-day interval) were examined histologically for axonal injury and behaviorally by the novel object recognition (NOR) task. The results from the current study demonstrate that an experimental closed head injury in the rodent with low mortality rates and absence of gross pathology can produce measurable cognitive deficits in a juvenile age group. The introduction of a second injury 24 h after the first impact resulted in increased axonal injury, astrocytic reactivity and increased memory impairment in the NOR task. The histological evidence demonstrates the potential usefulness of this RTBI model for studying the impact and time course of RTBI as it relates to the pediatric and young adult population. This study marks the first critical step in experimentally addressing the consequences of concussions and the cumulative effects of RTBI in the developing brain.Keywords
This publication has 46 references indexed in Scilit:
- Delayed reduction in hippocampal postsynaptic density protein-95 expression temporally correlates with cognitive dysfunction following controlled cortical impact in miceJournal of Neurosurgery, 2010
- Ontogeny of Rat Recognition Memory measured by the novel object recognition taskDevelopmental Psychobiology, 2009
- Integrated Imaging Approach with MEG and DTI to Detect Mild Traumatic Brain Injury in Military and Civilian PatientsJournal of Neurotrauma, 2009
- Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head InjuryJournal of Neuropathology and Experimental Neurology, 2009
- Multifocal White Matter Ultrastructural Abnormalities in Mild Traumatic Brain Injury with Cognitive Disability: A Voxel-Wise Analysis of Diffusion Tensor ImagingJournal of Neurotrauma, 2008
- Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: A diffusion tensor imaging (DTI) studyArchives of Clinical Neuropsychology, 2007
- Repetitive Mild Non-Contusive Brain Trauma in Immature Rats Exacerbates Traumatic Axonal Injury and Axonal Calpain Activation: A Preliminary ReportJournal of Neurotrauma, 2007
- Pediatric Sport-Related Concussion: A Review of the Clinical Management of an Oft-Neglected PopulationPEDIATRICS, 2006
- Neuropsychological and information processing deficits following mild traumatic brain injuryJournal of the International Neuropsychological Society, 2004
- Electrophysiological evidence for the cumulative effects of concussionBrain Injury, 2000