Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes
- 7 April 2011
- journal article
- research article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 31 (4), 247-253
- https://doi.org/10.1159/000327171
Abstract
Background/Aims: Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were genotyped for APOE, MTHFR and ICAM. A beta levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. Results: Associations were found between the APOE-epsilon 4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher A beta 1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity. Conclusions: The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates. Copyright (C) 2011 S. Karger AG, BaselKeywords
This publication has 44 references indexed in Scilit:
- Epidemiological Studies of the Effect of Stroke on Incident DementiaStroke, 2010
- Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivorsNeurobiology of Aging, 2007
- Quantification of Alzheimer pathology in ageing and dementia: age‐related accumulation of amyloid‐β(42) peptide in vascular dementiaNeuropathology and Applied Neurobiology, 2006
- Vascular cognitive impairmentThe Lancet Neurology, 2003
- Subcortical ischaemic vascular dementiaThe Lancet Neurology, 2002
- Cerebral infarcts in patients with autopsy-proven Alzheimer's diseaseNeurology, 1998
- Cytokines and adhesion molecules in stroke and related diseasesJournal of the Neurological Sciences, 1996
- A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductaseNature Genetics, 1995
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993
- Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America, 1993