Understanding the Mechanisms of Senile Osteoporosis: New Facts for a Major Geriatric Syndrome
- 1 May 2008
- journal article
- review article
- Published by Wiley in Journal of the American Geriatrics Society
- Vol. 56 (5), 935-941
- https://doi.org/10.1111/j.1532-5415.2008.01764.x
Abstract
Knowledge of the underlying mechanisms of osteoporosis in older adults has significantly advanced in recent years. There is an acute loss of bone mineral density in the peri-menopausal period, followed by a more gradual and progressive decline, which is also seen in men. Markedly increased bone resorption leads to the initial fall in bone mineral density. With increasing age, there is also a significant reduction in bone formation. This is mostly due to a shift from osteoblastogenesis to predominant adipogenesis in the bone marrow. This study reviews new evidence on the pathophysiology of senile osteoporosis, with emphasis upon the mechanism of action of current osteoporosis treatments. New potential treatments are also considered, including therapeutic approaches to osteoporosis in elderly people that focus on the pathophysiology and potential reversal of the adipogenic shift in bone.This publication has 64 references indexed in Scilit:
- Zoledronic Acid and Clinical Fractures and Mortality after Hip FractureThe New England Journal of Medicine, 2007
- Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitroBritish Journal of Pharmacology, 2007
- Once-Yearly Zoledronic Acid for Treatment of Postmenopausal OsteoporosisThe New England Journal of Medicine, 2007
- The antioxidant effect of estrogen and Selective Estrogen Receptor Modulators in the inhibition of osteocyte apoptosis in vitroBone, 2007
- Thiazolidinedione Use and Bone Loss in Older Diabetic AdultsJournal of Clinical Endocrinology & Metabolism, 2006
- Osteoporotic fractures in older adultsBest Practice & Research Clinical Rheumatology, 2006
- Playing with bone and fatJournal of Cellular Biochemistry, 2006
- Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticityBiogerontology, 2004
- Severe bone changes in a case of Hutchinson–Gilford syndromeAnnales de Genetique, 2002
- Calcitonin promotes osteoclast survival in vitroMolecular and Cellular Endocrinology, 1996